Dilutional Anemia of Splenomegaly

Mechanism of Dilutional Anemia

Twenty patients with anemia and massive splenomegaly were studied in order to elucidate the mechanism by which splenomegaly results in plasma volume expansion. In 18 patients, increased plasma volume accounted for most of the anemia. Fourteen patients had an exaggerated renin response to standing, mean 1967 ± 613 (SE) ng angiotensin 11/100 ml plasma (p < 0.05). The mean resting forearm blood fl...

Anemia and splenomegaly in cGKI-deficient mice.

To explore the functional significance of cGMP-dependent protein kinase type I (cGKI) in the regulation of erythrocyte survival, gene-targeted mice lacking cGKI were compared with their control littermates. By the age of 10 weeks, cGKI-deficient mice exhibited pronounced anemia and splenomegaly. Compared with control mice, the cGKI mutants had significantly lower red blood cell count, packed ce...

Clonidine-induced dilutional hyponatraemia.

Case report A 65-year-old woman was admitted with a 3-week history of persistent vomiting. She had been treated for several years for hypertension with clonidine 0'2 mg thrice daily, and chlorthalidone 50 mg twice daily. Initial investigations showed: serum sodium 131 mmol/l, potassium 2.6 mmol/l, chloride 90 mmol/l, bicarbonate 34 mmol/l, urea 7 mmol/l. She was treated with intravenous isotoni...

Splenomegaly, hypersplenism, and hereditary disorders with splenomegaly

Splenomegaly, sometimes of massive extent, occurs in a large number of hereditary diseases, some relatively prevalent and others, rare to ultra-rare. Because physicians are often unfamiliar with the less common disorders, patients may suffer because of diagnostic delay or diagnostic error and may undergo invasive, non-innocuous procedures such as splenectomy that are potentially avoidable were ...

The experimental production of splenomegaly, anemia and leukopenia in Albino rats.